Publications
2025
Unravelling the complex inflammatory landscape of COVID-19 infection: a pathway to biomarkers identification in infection-associated delirium in the ICU
T Born, M Perreau, PP Axisa, C Fenwick, A Pinto, N Ben-Hamouda, AO Rossetti, RD Pasquier, J-D Chiche, R Bernard-Valnet
Intensive Care Medicine Experimental; 12/2025
Transcriptomic profiling after B cell depletion reveals central and peripheral immune cell changes in multiple sclerosis
J Wei, J Moon, Y Yasumizu, L Zhang, K Radassi, N Buitrago-Pocasangre, ME Deerhake, N Strauli, C-W Chen, A Herman, R Pedotti, C Raposo, I Yim, J Pappalardo, EE Longbrake, TS Sumida, PP Axisa*, DA Hafler*
* equal contribution
The Journal of Clinical Investigation; 6/2025
Circulating tumor-reactive KIR+CD8+ T cells suppress anti-tumor immunity in patients with melanoma
BY Lu, LE Lucca, W Lewis, J Wang, CV Nogueira, S Heer, V Rayon-Estrada, PP Axisa, SM Reeves, NC Buitrago-Pocasangre, GH Pham, ML Kojima, Wei, L Aizenbud, A Bacchiocchi, L Zhang, JJ Walewski, V Chiang, K Olino, J Clune, R Halaban, Y Kluger, AJ Coyle, J Kisielow, F-J Obermair, HM Kluger, DA Hafler
Nature Immunology; 1/2025
2024
NK cells with adhesion defects and reduced cytotoxic functions are associated with a poor prognosis in multiple myeloma
E Blanquart, Rüçh Ekren, B Rigaud, M-Vér Joubert, V Baylot, Hélèn Daunes, M Cuisinier, M Villard, Nèg Carrié, Cél Mazzotti, LE Lucca, A Perrot, J Corre, T Walzer, Hé Avet-Loiseau, PP Axisa*, L Martinet*
* equal contribution
Blood; 9/2024
The tidyomics ecosystem: Enhancing omic data analyses
WJ Hutchison, TJ Keyes, T Consortium, HL Crowell, J Serizay, C Soneson, ES Davis, N Sato, L Moses, B Tarlinton, AA Nahid, M Kosmac, Q Clayssen, V Yuan, W Mu, J-E Park, I Mamede, MH Ryu, PP Axisa, P Paiz, C-L Poon, M Tang, R Gottardo, M Morgan, S Lee, M Lawrence, SC Hicks, GP Nolan, KL Davis, AT Papenfuss, MI Love, S Mangiola
Nature methods; 7/2024
2023
TCR-independent CD137 (4-1BB) signaling promotes CD8+-exhausted T cell proliferation and terminal differentiation
AC Pichler, Nèg Carrié, M Cuisinier, S Ghazali, A Voisin, PP Axisa, M Tosolini, Cél Mazzotti, DP Golec, S Maheo, LD Souto, Rüçh Ekren, E Blanquart, L Lemaitre, V Feliu, M-Vér Joubert, JL Cannons, C Guillerey, Hé Avet-Loiseau, TH Watts, BL Salomon, O Joffre, Y Grinberg-Bleyer, PL Schwartzberg, LE Lucca, L Martinet
Immunity; 7/2023
2022
A multiple sclerosis–protective coding variant reveals an essential role for HDAC7 in regulatory T cells
PP Axisa, TM Yoshida, LE Lucca, HG Kasler, MR Lincoln, GH Pham, DD Priore, J-M Carpier, CL Lucas, E Verdin, TS Sumida, DA Hafler
Science Translational Medicine; 12/2022
Impaired TIGIT expression on B cells drives circulating follicular helper T cell expansion in multiple sclerosis
H Asashima, PP Axisa, THG Pham, EE Longbrake, WE Ruff, N Lele, I Cohen, K Raddassi, TS Sumida, DA Hafler
The Journal of Clinical Investigation; 10/2022
Type I interferon transcriptional network regulates expression of coinhibitory receptors in human T cells
TS Sumida, S Dulberg, JC Schupp, MR Lincoln, HA Stillwell, PP Axisa, M Comi, A Unterman, N Kaminski, A Madi, VK Kuchroo, DA Hafler
Nature Immunology; 4/2022
2021
Circulating clonally expanded T cells reflect functions of tumor-infiltrating T cells
LE Lucca, PP Axisa, B Lu, B Harnett, S Jessel, L Zhang, K Raddassi, L Zhang, K Olino, J Clune, M Singer, HM Kluger, DA Hafler
Journal of Experimental Medicine; 3/2021
2020
Epigenetic fine-mapping: identification of causal mechanisms for autoimmunity
MR Lincoln, PP Axisa*, DA Hafler
* corresponding author
Current Opinion in Immunology; 12/2020
2019
TIGIT signaling restores suppressor function of Th1 Tregs
LE Lucca, PP Axisa, ER Singer, NM Nolan, M Dominguez-Villar, DA Hafler
JCI insight; 2/2019
2017
Podoplanin is a negative regulator of Th17 inflammation
AN Nylander, GD Ponath, PP Axisa, M Mubarak, M Tomayko, VK Kuchroo, D Pitt, DA Hafler
JCI insight; 9/2017
2016
Myelin oligodendrocyte glycoprotein induces incomplete tolerance of CD4+ T cells specific for both a myelin and a neuronal self‐antigen in mice
LE Lucca*, PP Axisa*, M Aloulou, C Perals, A Ramadan, P Rufas, B Kyewski, J Derbinski, N Fazilleau, LT Mars, RS Liblau
* equal contribution
European journal of immunology; 9/2016
Multiple sclerosis: genetics, biomarkers, treatments
PP Axisa, DA Hafler
Current opinion in neurology; 6/2016
In situ expansion of T cells that recognize distinct self-antigens sustains autoimmunity in the CNS
A Ramadan, LE Lucca, N Carrie, S Desbois, PP Axisa, M Hayder, J Bauer, RS Liblau, LT Mars
Brain; 5/2016